Iranian Journal of Nursing and Midwifery Research1735-90662122016040315964ENNursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, IranNursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran20160403<p><strong>Background:</strong> Premenstrual syndrome (PMS) can cause problems in daily work and relationships.</p><p><strong>Materials and Methods:</strong> Eighty‑six women were randomly assigned to two intervention groups and one control group. Patients were asked to fill out the PMS Daily Symptoms Record for 2 months, and then the participants were randomly assigned to one of the three study groups. Medical intervention was carried out for 2 months with the participants in each group receiving either a tablet containing 200 mg vitamin D, 100 mg vitamin E, or a placebo each day, respectively. After 2 months, the results of pre‑ and post‑intervention were compared. P &lt; 0.005 was considered significant.</p><p><strong>Results:</strong> After the intervention, the mean score of the syndrome significantly decreased in all the three groups (12, 16, and 8 participants had decreased scores in vitamin D, vitamin E, and placebo,  respectively). The differences between groups were not significant (P &gt; 0.05).</p><p><strong>Conclusions:</strong> Supplemental therapy with vitamins D and E is an effective and affordable treatment for PMS.</p><p> </p>http://ijnmr.mui.ac.ir/index.php/ijnmr/article/view/1294http://ijnmr.mui.ac.ir/index.php/ijnmr/article/download/1294/996