Iranian Journal of Nursing and Midwifery Research1735-9066221201703156771ENDepartment of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran,IranDepartment of Midwifery and Reproductive Health, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pediatrics Arak University of Medical Sciences, Arak, IranDepartment of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran20170315<p><strong>Introduction: </strong>Infantile colic is a painful condition in the first months of infancy. This study was carried out with the aim of testing the hypothesis that massage treatment has a clinically relevant effect on this condition.</p><p> <strong>Materials and Methods: </strong>This randomized clinical trial was conducted among 100 infants of &lt;12 weeks of age with infantile colic. They were randomly assigned to either infant massage (<em>n </em>= 50) or rocking groups (<em>n </em>= 50). In the massage group, trained individuals taught the parents of the infants the massage technique and gave them a brochure. Rocking group parents was recommended to rock their infants three times a day for 1 week. Parents recorded the pattern of crying (numbers, length, and severity of crying). After 1 week of intervention, data were analysed using <em>t</em>‑test, Chi square test, and repeated measurement analysis of variance (<em>P </em>&lt; 0.05).</p><p> <strong>Results: </strong>Significant differences were not observed in infant and mother demographic information. Before intervention, the mean of total number, length, and severity of crying were 6.12 (1.76) time/day, 4.97 (1.37) hour/day, and 6.60 (1.54) in the massage group and 6.96 (2.9) time/day, 3 (1.31) hour/day, and 5.98 (2.22) in the rocking group, respectively. After 1 week of intervention, the mean difference of total number, length, and severity of crying were 4.08 (1.83) time/day, 2.81 (1.77) hour/day, and 2.9 (2.37) in the massage group and 0.56 (2.28) time/day, 0.27 (1.09) hour/day, and 0.02 (1.64) in the rocking group, respectively.</p><p> <strong>Conclusions: </strong>This trial of massage treatment for infantile colic showed statistically significant or clinically relevant effect in comparison with the rocking group.</p>http://ijnmr.mui.ac.ir/index.php/ijnmr/article/view/1410http://ijnmr.mui.ac.ir/index.php/ijnmr/article/download/1410/1110