Iranian Journal of Nursing and Midwifery Research1735-906625420200618282285ENDepatment of Midwifery, Sirjan School of Medical Sciences, Kerman University of Medical Sciences, Kerman, IranDepatment of Nursing, Sirjan School of Medical Sciences, Sirjan, IranInstructor of Biostatistics, Sirjan School of Medical Sciences, Sirjan, Iran2020062120200621<p><strong>Background: </strong>Nipple fissure is a common problem among breastfeeding women, which can  lead to early cessation of breastfeeding. Because of the lack of effective treatment and given the  approved efficacy of honey and yarrow on sore healing, this study was conducted to evaluate  and compare the effects of yarrow, honey, and breast milk on the treatment of nipple fissure. </p><p><strong>Materials and Methods: </strong>This study was a three‑group clinical trial, and sampling was conducted  at Sina breastfeeding counseling center from September 2016 to March 2018 in Sirjan, Iran, using  a target‑based method. The sample size consisted of 150 individuals who were randomly assigned  into three groups as topical use of yarrow, the mountain honey, and breast milk after obtaining the  written informed consent. The correct method of breastfeeding and using materials were instructed to  these three groups on the 1st, 3rd, and 7th days, where the Storr scale was completed by the researcher. </p><p><strong>Results: </strong>Friedman test showed that, in these three groups of yarrow (<em></em>2 = 92.19, df = 2, <em>p </em>&lt; 0.001),  honey (<em></em>2 = 93.29, df = 2, <em>p </em>&lt; 0.001), and breast milk (<em></em>2 = 90.51, df = 2, <em>p </em>&lt; 0.001)); severity  of fissure had a significant reduction. Nevertheless, Kruskal–Wallis test revealed no significant  difference among the severity of fissure scores in these three groups (<em>p </em>&gt; 0.05).</p><p><strong>Conclusions: </strong>Use  of honey, yarrow, and breast milk can be recommended to women in breastfeeding counseling and  pharmaceutical companies can be advised to use honey and yarrow in the preparation of anti‑fissure  creams. </p>http://ijnmr.mui.ac.ir/index.php/ijnmr/article/view/1722http://ijnmr.mui.ac.ir/index.php/ijnmr/article/download/1722/70707294