The effect of polycystic ovary syndrome on outcome of assisted reproductive technology in Isfahan Infertility Center in 2003

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a very common endocrine disorder in infertile women with anovulatory cycle. This disorder is associated with abnormal circulating hormones. The response of ovaries to induction of ovulation is a controversial issue and can have different results. This study tried to compare the results of induction for ovulation in 130 patients who had polycystic ovary syndrome with those of 130 women who had tubal factor for infertility and had normal ovaries.

Methods: In this prospective study, there were 260 women having PCOS and tubal infertility, undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment in Isfahan Infertility Center. The number of oocyte, concentrations of testosterone and restandol, fertility rate and the quality of embryo were compared.

Results: The findings showed that the mean number of oocytes retrieved (13.1 versus 8.04), concentration of restandol in follicular and LHO phases and testosterone in LHO phase were higher in PCOS patients. The fertilization rate in PCOS patients (64%) showed no difference with those who had tubal factor (67%).

Conclusion: The findings showed that the induction of ovulation in PCOS is followed by increasing serum androgen concentration through its effect on early embryonic development. But, due to the high number of oocytes in PCOS patients versus patients with normal ovaries, the chance of forming more embryos with ideal quality is increased in these patients.emi