The Effect of Resistance Exercise on Lipid Profile of Coronary Artery Disease Patients: A Randomized clinical trial

Zahra Salehi, Kobra Salehi, Mahin Moeini, Mehdi Kargarfard, Masoumeh Sadeghi


Background: Increased level of blood lipids is one of the risk factors for cardiovascular diseases. Considerable research has done to assess the effects of physical exercises on lipid profile, of which aerobic exercises are the main part of evidence. However, in recent years, resistance exercise has been less investigated. Thus, the present study investigates the effect of resistance exercise on lipid profile in coronary artery disease patients.

Materials and Methods: This study was a randomized clinical trial. Forty eligible participants were selected through selective sampling and were assigned randomly to either intervention or control groups (20 participants in each group). Fasting blood sample was taken for measurement of lipid profile before, after, and after 4 weeks of the end of intervention. The intervention period lasted 8 weeks and included two exercise sessions of 45– 60 minutes per week. Resistance exercise was performed by use of light weights in the range of motion of the elbow, shoulder, and knee joints. The number of repetitions was initially 10 and was gradually increased to 15. Then, the weight was increased by 3–5% and the number of sets too. Data were analyzed on significant level of P < 0.05. Results: In both the groups, the mean and mean changes of lipid profile, before, after. and 4 weeks after the end of the intervention were not significantly different (P < 0.05).

 Conclusions: The 8‑week of resistance exercise did not lead to a significant decrease in the mean lipid profile.


Coronary artery disease; lipids; resistance training

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Ghalamghash R, Gushe B, Omrani A, Keihani M, Fallahi A. The Effect Of Cardiac Rehabilitation On Functional Capabilities Of Patients With Valvular Heart Surgery. Journal of Medical Council of Islamic Republic of Iran 2008;26:213‑21. [In Persian].

Kargarfard M, Basati F, Sadeghi M, Rouzbehani R, Golabchi A. Effects of a cardiac rehabilitation program on diastolic filling properties and functional capacity in patients with myocardial infarction. J Isfahan Medical School 2011;29:243‑52.

Achari V, Thakur A. Association of major modifiable risk factors among patient with coronary artery disease: A retrospective analysis. J Assoc Physicians India 2004;52:103‑8.

Esteghamti A, Abbasi M, Nakhgavani M, Yousefizadeh A, Basa A, Afshar H. Prevalance of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome. Cardiovasc Diabetol 2006;5:15.

Tabatabaei‑Malazy O, Qorban MI, Samavat T, Sharifi F, Larijani B, Fakhrzadeh H. Prevalence of Dyslipidemia in Iran: A Systematic Review and Meta‑Analysis Study. Int J Prev Med 2014;5:373‑93.

Sadeghi M, Roohafza HR, Shirani SH, Baghaie AM, Golshadi I, Aghdak P. Relationship between hematological factors and metabolic syndrome in an Iranian Population Isfahan Healthy Heart Program. JRUMS 2006;5(2):109‑16. [In Persian].

Yeh G, Wang C, Wayne P, Phillips R. Thi chi exercise for patients with cardiovascular condition and risk factors: A systematic review. J Cardiopulm Rehabil Prev 2009;29:152‑60.

Naghii M, Almadadi M. Effect of Regular Physical Activity as a Basic Component of Lifestyle Modification on Reducing Major Cardiovascular Risk Factors. Knowl Health 2011;6:27‑35.

Oliveira J, Galvao C, Rocha S. Resistance exercise for health promotion in coronary patient: Evidence of benefits and risks. Int J Evid Based Health 2008;6:431‑9.

Ormsbee M, Ormsbee J, Thyfault E, Raymond M, Myung D, Robert C. Fat metabolism and acute resistance exercise in trained men. J App Physiol 2007;102:1767‑72.

Kisner C, Colby L. Therapiutic exercise: Foundation and techniques. USA: Davis Plus; 2007. p. 148.

Rose B, Keegan L. Exercise and movement. In: Montgomery B, Keegan D, Keegan L, editors. Holistic nursing. USA: Jones and Bartlet; 2009. p. 232‑6.

Misra A, Alappan N, Vikram N, Goel K, Gupta N, Mittal K, et al. Effect of supervised progressive resistance exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in asian Indians with type 2 diabetes. Diabetes Care 2008;31:1282‑7.

Okada S, Hiuge A, Naguma H, Makino H, Takaki H, Konishi H. Effect of exercise, intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes. Atheroscler Thromb 2010;17:828‑33.

Heffernan K, Fahs C, Iwamoto G, Jae S, Wilund K, Woods J, et al. Resistance exercise training reduces central blood pressure and improves microvascular function in African American and white men. Atherosclerosis 2009;207:220‑6.

Leon A. Exercise following myocardial infarction. Sports Med 2000;29:301‑11.

Moeini M, Salehi K, Salehi Z, Kargarfard M, Sadeghi M. Effect of resistance exercise on fasting blood glucose and 2 hourse after in coronary artery disease patient: Randomized clinical trial. J Clin Nurs Midwifery 2014;3:28‑36.

Davoodvand S, Elahi N, Haghighizadeh M. Effectiveness of Short‑term Cardiac Rehabilitation on Clinical Manifestations in Post‑MI Patients. J Fac Nurs Midwifery 2009;15:63‑73.

Akbarnejad A, Souri R, Sayyah M, Bigdeli M. The Comparison of the Effects of Intermittent and Continuous Training Programs on Some Selected Cardiovascular Risk Factors in Obese Young Females. J Sports Biosci 2011;3:77‑93.

Loimaala A, Groundstroem K, Rinne M, Nenonen A, Huhtala H, Parkkar IJ, et al. Effect of Long‑Term Endurance and Strength Training on Metabolic Control and Arterial Elasticity in Patients With Type 2 Diabetes Mellitus. Am J Cardiol 2009;103:972‑7.

Elliott K, Sale C, Cable N. Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women. Br J Sports Med 2002;36:340‑5.

Berent R, von Duvillard S, Crouse S, Sinzinger H, Green J, Schmid P. Resistance Training Dose Response in Combined Endurance‑Resistance Training in Patients With Cardiovascular Disease: A Randomized Trial. Arch Phys Med Rehabil 2011;92:1527‑33.

Zotou E, Magkos F, Koutsari C, Fragopoulou E, Nomikos T. Acute resistance exercise attenuates fasting and postprandial triglyceridemia in women by reducing triglyceride concentrations

in triglyceride‑rich lipoproteins. Eur J Appl Physiol 2010;110:869‑74.

Mogharnasi M, Bagheri M. The Effect of 12 Weeks of Circuit Resistance Training on C‑Reactive Protein and Lipid Profile in Inactive Women. J Sports Biosci 2014;6:233‑44.

Jafari A, Zamani AR. The effect of 8 weeks of Concurrent Interval endurance training and resistance training and continuous endurance and resistance training on power, body composition, lipid profile in overweight, non‑athletes 14‑17 years boys. J Sports Biosci 2012;15:5‑22.


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