Relationship between C-reactive Protein and Screening Test Results of Gestational Diabetes in Pregnant Women Referred to Health Centers in Isfahan in 2013–2014

Maryam Kianpour, Farzaneh Saadatmand, Mehdi Nematbakhsh, Fariba Fahami

Abstract


Background: Gestational diabetes is the second common disorder in pregnancy period, which is detected in 24–28 weeks of gestational age through screening tests. Low‑grade systematic inflammation is associated with an increased risk of type 2 diabetes. C–Reactive Protein (CRP), an acute phase protein produced by hepatocytes, may be associated with diabetes. This study aimed to investigate serum levels of CRP in women with Gestational Diabetes Mellitus (GDM) and impaired glucose tolerance test compared with control subjects.

Materials and Methods: This observational longitudinal study was conducted on 176 pregnant women in Isfahan. After administration of a CRP test in these women in the first trimester, a screening test of Glucose Challenge Test (GCT) with 50‑g oral glucose was conducted in 24–28 weeks of gestational age. Then, CRP levels and GCT were compared.

Results: Serum CRP levels were not significantly correlated with positive GCT among the women. In GDM patients, there was not a significant correlation between CRP and BMI.

Conclusions: There was no significant correlation between maternal serum CRP level and gestational diabetes. Maternal serum CRP level in the first trimester cannot predict Intolerance Glucose Test (IGT) in 26–30 weeks of gestational age.


Keywords


Body mass index, C - reactive protein, inflammation, pregnancy, screening test for gestational diabetes mellitus

References


Cuningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Westrom KD. Text Book of Williams’s Obstetrics: Diabetes Mellitus. 25th ed., 1 and 2. New York: Mc Graw Hill Company; 2018. P. 1317‑19.

Georgiou HM, López SI, Rice GE. (November 2nd 2011). Novel screening approaches for the early detection of gestational diabetes mellitus. Gestational Diabetes, Miroslav Radenkovic, IntechOpen, DOI: 10.5772/21976. Available from: https://www. intechopen.com/books/gestational‑diabetes/novel‑screening‑ approaches‑for‑the‑early‑detection‑of‑gestational‑diabetes‑ mellitus. [Last accessed on 2011 Nov 02].

Hunt KJ, Schuller KL. The increasing prevalence of diabetes in pregnancy. Obstet Gynecol Clin North Am 2017;34:173‑99.

Gibbs RS, Danforth DK, Karlan BY, Haney AF. Danforth Obstetrics and Gynecology. 10th ed. Philadelphia: Lippincott Williams and Wilkins; 2008. P. 1317‑19.

Ardakani M, Rashidi M. Gestational diabetes. Hormozgan Med Sci 2007;1:1‑12.

Meybodi F, Mahmodi M, Hassani M. Attitude of gestational diabetes in pregnant women to health centers in Kerman University of medical sciences. Razi Med 2011;11:17‑24.

Diabetes in Pregnancy. Management of diabetes and its complications from preconception to the postnatal period. 2018. Available from: http://www.rcog.org.uk. [Last accessed on 2008].

Farasel R, James D, Steer P, Weiner C, Gonik B. High Risk Pregnancy. 4th ed. China: Elsevier Saunders publisher; 2011.

Myles W, Laura S, Karen H, Jeffrey L, Ravi T. First –trimester’s C‑reactive protein and subsequent gestational diabetes. Diabetes Care 2003;26:819‑24.

Pendergrass M, Fazioni E, Defronzo RA. Non‑insulin dependent diabetes mellitus and gestational diabetes mellitus: Same disease, another name. Diabetes Rev 1995;3:566‑83.

Clark CMU, Qiu C, Amerman B, Porter B, Fireberg N, Aldasouqi S. Gestational diabetes: Should it be added to the syndrome of insulin resistance. Diabets Care 1997;20:867‑71.

Mojibian M, Soheilykhan S, Rahimi Saghand S, Rashidi M. Maternal serum C‑reactive protein concentration in gestational diabetes. Iran J Diabetes Obesity 2011;3:2.

Ridker PM, Cushman M, Stemfer MJ, Tracy RP, Hannekens CH. Inflamation, aspirin and the risk of cardiovascular disease in apparently health men. Engel J Med 1997;336:9973‑9.

Paradhan AD, Manson JE, Rifai N, Buring J, Ridker PM. C‑reactive protein interleukin 6 and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327‑34.

Freeman DJ, Norrie J, Caslake MJ, Fard I, Lowe G, Oreilly D, et al. C‑reactive protein is an independent predictor of risk for the development of diabetes in the west of Scotland coronary prevention study. Diabets 2002;51:1596‑600.

Li X, Lu X. Study correlation between C‑reactive protein and gestational Diabetes mellitus. Obstet Gynecol 2007;21:382‑5.

Najafipour F, Aliasgharzadeh A, Bahrami A, Niafar M, Mobasseri M. Prevalency of diabetic nephropathy among type 2 diabetic patients. J Gorgan Uni Med Sci 2009;11:62‑6.

Garshasbi A, Zamirry A, Faghihzadeh S, Naghizadeh MM. Comprative evaluation of fasting plasma glucose and one hour 50‑gr glucose challenge test in screening gestational diabetes mellitus. Zanjan Univ Med Sci J 2010;18:1‑12.

Yachi Y, Tanaka Y, Anasako Y, Nishibata I, Saito K, Sone H, et al. Contribution of first trimester fasting plasma insulin levels to the incidence of glucose intolerance in later pregnancy: Tanaka women s clinic study. Diabetes Res Clin Pract 2011;92:293‑8.

Kashi Z, Borzouei SH, Akha O, Moslemzadeh N, Zakeri HD, Mohammad Poor A. Diagnostic value of fasting plasma glucose in screening of gestational diabetes mellitus. Int Endocrinology Metab 2007;1:5‑8.

Lopolla A, Dalfra MG, Mello G, Parretti E, Cioni R, Marzari C. Early detection of insulin sensitivity and B‑cell function with simple test indicates future derangements in late pregnancy. J Clin Endocrinol Metab 2008;93:876‑80.

Riskin‑Mashiah S, Damit A, Younes G, Auslender R. First trimester fasting hyperglycemia as a predictor for the development of gestational diabetes mellitus. Eur J Obster Gynecol Reprod Biol 2010;152:163‑7.

Torloni MR, Betrán AP, Horta BL, Nakamura MU, Atallah AN, Moron AF, et al. Prepregnancy BMI and the risk of gestational diabetes: A systematic review of the literature with meta‑analysis. Obes Rev 2009;10:194‑203.

Grewal E, Kansara S, Kachhawa G, Ammini AC, Kriplani A, Aggarwal N, et al. Predict of gestanal diabetes mellitus at 24 to 28 weeks of gestational by using first‑trimester insulin sensivity indices in Asian Indian subjects. Metabolism 2012;61:715‑20.

Mirfeizi M, Mehdizadeh Tooeazani Z, Asghari Jafarabedi M, Gholami M, Moniri Tekmehdash A. Examining diagnostic value of the fasting plasma glucose in screening gestational Diabetes. Iran J Diabetes Lipid Dis 2011;10:1‑5.

Ben‑Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med 2003;21:103‑13.

Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley RE. Circulating interleukin‑6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 2011;9:414‑7.

Ford ES. Body mass index, diabetes, and C‑reactive protein among U.S. adults. Diabetes Care 1999;22:1971‑7.


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