Comparing the Effects of Yarrow, Honey, and Breast Milk for Healing Nipple Fissure

Maryam Firouzabadi, Naimeh Pourramezani, Mohadeseh Balvardi


Background: Nipple fissure is a common problem among breastfeeding women, which can  lead to early cessation of breastfeeding. Because of the lack of effective treatment and given the  approved efficacy of honey and yarrow on sore healing, this study was conducted to evaluate  and compare the effects of yarrow, honey, and breast milk on the treatment of nipple fissure. 

Materials and Methods: This study was a three‑group clinical trial, and sampling was conducted  at Sina breastfeeding counseling center from September 2016 to March 2018 in Sirjan, Iran, using  a target‑based method. The sample size consisted of 150 individuals who were randomly assigned  into three groups as topical use of yarrow, the mountain honey, and breast milk after obtaining the  written informed consent. The correct method of breastfeeding and using materials were instructed to  these three groups on the 1st, 3rd, and 7th days, where the Storr scale was completed by the researcher. 

Results: Friedman test showed that, in these three groups of yarrow (2 = 92.19, df = 2, p < 0.001),  honey (2 = 93.29, df = 2, p < 0.001), and breast milk (2 = 90.51, df = 2, p < 0.001)); severity  of fissure had a significant reduction. Nevertheless, Kruskal–Wallis test revealed no significant  difference among the severity of fissure scores in these three groups (p > 0.05).

Conclusions: Use  of honey, yarrow, and breast milk can be recommended to women in breastfeeding counseling and  pharmaceutical companies can be advised to use honey and yarrow in the preparation of anti‑fissure  creams. 


Achillea, breast feeding, honey, Iran, milk, nipples

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Abd-Elsalam S, Hamido S, Abd el Hameed H. Effect of using pharmacological versus alternative therapy on traumatic nipples for lactating mothers. J Am Sci 2011;7:485‑96.

Tafazoli M, Saeedi R, Gholami Robatsangi M, Mazloom R. Aloevera gel Vs. lanolin ointment in the treatment of nipple sore: A randomized clinical trial. Tehran Univ Med J 2010;67:699‑704.

Marrazzu A, Sanna MG, Dessole F, Capobianco G, Piga MD, Dessole S. Evaluation of the effectiveness of a silver‑impregnated medical cap for topical treatment of nipple fissure of breastfeeding mothers. Breastfeed Med 2015;10:232‑8.

Eshgizade M, Moghaddam MB, Moghaddam HM, Mahmoudian A, Mina M. Comparison of the effect of olive oil, aloe vera extract and breast milk on healing of breast fissure in lactating mothers: A randomized clinical trial. Qom Univ Med Sci J 2016;10:19-27.

Kazemirad M, Khodakarami N, Salamzadeh J, Nasiri N, Kazemi M, Moattar F. Comparison of calendit‑e cream versus expressed breast milk. Adv Nurs Midwifery 2013;23:53‑80.

Akbari SAA, Alamolhoda SH, Baghban AA, Mirabi P. Effects of menthol essence and breast milk on the improvement of nipple fissures in breastfeeding women. J Res Med Sci 2014;19:629‑33.

Sheinizadeh‑Emadi S, Ehsani P, Dahanzadeh S. Comparison evaluation of Curcumin (Curcuma longa extract) with the application of expressed breast milk in the treatment of nipple cracks in lactating primiparous women: A randomized clinical trial. J Clin Nurs Midwifery 2015;4:11‑9.

Morrison AH, Gentry R, Anderson J. Mothers’ reasons for early breastfeeding cessation. MCN Am J Matern Child Nurs 2019;44:325‑30.

Shanazi M, Khalili AF, Kamalifard M, Jafarabadi MA, Masoudin K, Esmaeli F. Comparison of the effects of lanolin, peppermint, and dexpanthenol creams on treatment of traumatic nipples in breastfeeding mothers. J Caring Sci 2015;4:297‑307.

Potrich FB, Allemand A, da Silva LM, dos Santos AC, Baggio CH, Freitas CS. et al. Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: Involvement of the antioxidant system. J Ethnopharmacol 2010;130:85‑92.

Hajhashemi M, Ghanbari Z, Movahedi M, Rafieian M, Keivani A, Haghollahi F. The effect of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women. J Maternal‑Fetal Neonatal Med 2018;31:63‑9.

Parandin R, Ghorbani R, Roodsari HS. Effects of alcoholic extract of Achillea millefolium flowers on fertility parameters in male rats. JSSU 2011;19:84-93.

Tadić V, Arsić I, Zvezdanović J, Zugić A, Cvetković D, Pavkov S. The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti‑inflamatory potential in topical application. J Ethnopharmacol 2017;199:138‑48.

Al‑Waili N, Salom K, Al‑Ghamdi AA. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. ScientificWorldJournal 2011;11:766‑87.

Mohamed H, Salma M, Al BL, Abdi S, Gouda Z, Barakat N, et al. The efficacy and safety of natural honey on the healing of foot ulcers: A case series. Wounds 2015;27:103‑14.

Saha A, Chattopadhyay S, Azam M, Sur PK. The role of honey in healing of bedsores in cancer patients. South Asian J Cancer 2012;1:66‑71.

Dorjsembe B, Lee HJ, Kim M, Dulamjav B, Jigjid T, Nho CW. Achillea asiatica extract and its active compounds induce cutaneous wound healing. J Ethnopharmacol 2017;206:306‑14.

Saeidi R, Tafazoli M, Gholami M, Mazloom R. New treatment for nipple soreness in breastfeeding mothers: A clinical trial study. IJN 2015;6:48‑51.

Amooie AM, Mojahed M, Mojahed M. Entrepreneurship Package of Yarrow Production. 1st ed. Tehran: Asrare Elm; 2016. p. 45.

As’adi N, Kariman N, Mojab F, Pourhoseingholi MA. The effect of Saqez (Pistacia atlantica) ointment on nipple fissure improvement in breastfeeding women during one‑month follow‑up. Avicenna J Phytomed 2017;7:477‑85.

Benedek B, Kopp B, Melzig MF. Achillea millefolium L. s.l. ‑‑ is the anti‑inflammatory activity mediated by protease inhibition? J Ethnopharmacol 2007;113:312‑7.

Morland‑Schultz K, Hill PD. Prevention of and therapies for nipple pain: A systematic review. J Obstet Gynecol Neonatal Nurs 2005;34:428‑37.


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